Day 1: Monday, September 14, 2026
| Time | Program | Speaker |
| All Day | Badge Pickup (Pavillion Lobby) | |
| 7:30 AM – 8:30 AM | Breakfast (Prefunction Space 1) | |
| 8:30 AM – 9:00 AM | Opening Remarks – Introduction and History of AI Core – Remarks from UVA (Host Institution) | Madhav Marathe (UVA) Thomas Potok (ORNL) Lori McMahon (UVA) Naren Ramakrishnan (VT) |
| 9:00 AM – 9:45 AM | Keynote: The Genesis Mission: A Federation for AI-Driven Science Session Chair: Madhav Marathe (UVA) | Georgia Tourassi (ORNL) |
| 9:45 AM – 10:15 AM | Coffee Break (Prefunction Space 1) | |
| 10:15 AM – 11:45 AM | Talk Session Session Chair: Keita Taranishi (ORNL) | |
| 10:15 AM – 10:45 AM | Mechanistic Interpretability of Protein Folding in Alphafold 2 and ESM 2 | Aidong Zhang (UVA) |
| 10:45 AM – 11:15 AM | Topology-Driven Diffusion for Adverse Spatio-Temporal Event Surveillance | Yulia Gel (VT) |
| 11:15 AM – 11:45 AM | Advances in Neuromorphic Computing | Robert Patton (ORNL) |
| 11:45 AM – 12:45 PM | Lunch (Prefunction Space 1) | |
| 12:45 PM – 1:45 PM | Panel Discussion: “Who Does the Science?“ Moderator: Ferdinando Fioretto (UVA) | YY Ahn (UVA), Tom Hartvigsen (UVA), Dongkuan Xu (NCSU), and Guojing Cong (ORNL) |
| 1:45 PM – 2:30 PM | Keynote: AI Agents, Guardrails, and the Pace of Scientific Discovery Session Chair: Prasanna Date (ORNL) | Ryan Wright (UVA) |
| 2:30 PM – 3:00 PM | Coffee Break (Prefunction Space 1) | |
| 3:00 PM – 4:30 PM | Talk Session Session Chair: Seung-Hwan Lim (ORNL) | |
| 3:00 PM – 3:30 PM | AI in High-Stakes Allocation: Judgment and Uncertainty | Sanmay Das (VT) |
| 3:30 PM – 4:00 PM | Navigating Scientific Knowledge: Toward Autonomous and Personalized AI Scientists | Tyler Derr (Vanderbilt) |
| 4:00 PM – 4:30 PM | Dual Inductive Biases In Brain Evolution | Nabil Imam (GT) |
| 4:30 PM – 5:30 PM | Genesis Mission Project Panel Session Chair: Forrest Hoffman (ORNL) | Prasanna Date (ORNL), Ramakrishnan Kannan (ORNL), Xiuwen Liu (FSU), Ferdinando Fioretto (UVA), Joshua Fu (UTK) |
| 6:30 PM – 8:30 PM | Banquet Dinner (The Arbor Room & The Hearth Room at The Mill Room Restaurant, Boar’s Head Resort) Briefing on the Genesis Mission Platform ORNL AI CORE 2027 Workshop | Zach Mayes (ORNL) Xiuwen Liu (FSU) |
Day 2: Tuesday, September 15, 2026
| Time | Program | Speaker |
| All Day | Badge Pickup (Pavillion Lobby) | |
| 7:30 AM – 8:40 AM | Breakfast (Prefunction Space 1) | |
| 8:40 AM – 9:00 AM | Opening Remarks – Summary of Day 1 & Plans for Day 2 – An Invitation to Collaborate | Prasanna Date (ORNL) Frederick Epstein (UVA) |
| 9:00 AM – 9:45 AM | Keynote: Power-Aware Computing in the Age of AI Session Chair: Ramakrishnan Kannan (ORNL) | Kirk Cameron (VT) |
| 9:45 AM – 10:15 AM | Coffee Break (Prefunction Space 1) | |
| 10:15 AM – 11:15 AM | Panel Discussion: Accelerating Discovery: AI’s Role in the Next Era of Science Moderator: Michael Parks (ORNL) | Hai Li (Duke) Guannan Zhang (ORNL) Stephen Turner (UVA) Dawei Zhou (VT) Raju Vatsavai (NCSU) |
| 11:15 AM – 1:15 PM | Poster Session (Prefunction Space 2 & 3 + Pavilion 3) & See poster details Lunch (Prefunction Space 1) 11:15 AM – 11:45 AM: Info Session on ORNL Programs for Undergrads 11:45 AM – 12:14 PM: Info Session on ORNL Programs for Grads & Faculty | William Jenks (ORNL) |
| 1:15 PM – 3:00 PM | Talk Session Session Chair: Jong Youl Choi (ORNL) | |
| 1:15 PM – 1:45 PM | Robustness as a First-Class Citizen in Trustworthy AI: Computation, Modeling, and Adaptivity | Xiaorui Liu (NCSU) |
| 1:45 PM – 2:15 PM | Deep Learning Guided Discovery of Synthetically Complex Peptides using Hierarchical Graph Networks | Camille Bilodeau (UVA) |
| 2:15 PM – 2:45 PM | Edge AI: Everything, Everywhere, All at Once | Yiran Chen (Duke) |
| 2:45 PM – 3:15 PM | Closing the Neuromorphic Computing Loop: From Algorithms and Exascale Simulation to Edge Hardware | Ashish Gautam (ORNL) |
| 3:15 PM – 3:30 PM | Closing Remarks | Ramakrishnan Kannan (ORNL), Madhav Marathe (UVA, and Xiuwen Liu (FSU) |